Cytochrome P450 polyclonal antibody



ADI-MFO-100-D	50 µg	200.00 USD

ADI-MFO-100-F	200 µg	439.00 USD
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Product Details

Alternative Name:	CYPR

Host:	Rabbit

Immunogen:	Native rat Cytochrome p450.

UniProt ID:	P05182

GenBank ID:	M20131

Source:	Purified from rabbit serum.

Species reactivity:	Human, Mouse, Rat Clam, Dog, Guinea pig, Horse, Monkey, Rabbit

Applications:	WB

Recommended Dilutions/Conditions:	Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Application Notes:	Detects a band of ~50-55 kDa by Western blot.

Purity Detail:	Protein A affinity purified.

Formulation:	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.

Handling:	Avoid freeze/thaw cycles.

Shipping:	Blue Ice

Long Term Storage:	-20°C

Scientific Background:	Cytochrome p450 is a highly conserved and diverse family of heme-containing proteins that function in the metabolism of numerous endogenous and exogenous substrates.. The human genome encodes 57 p450 genes divided among 18 families, which together account for the diversity of substrates metabolized. p450 is the primary conjugating enzyme in phase I metabolism and detoxification of endogenous and exogenous compounds, and are primarily localized to the inner membranes of mitochondria and the ER. Eukaryotic microsomal cytochrome p450 enzymes receive electrons from the FAD- and FMN-containing enzyme NADPH:cytochrome p450 reductase (CPR).

Regulatory Status:	RUO - Research Use Only

Cytochrome P450 polyclonal antibody Western blot

Western blot analysis of Cytochrome P450: Lane 1: MWM, Lane 2: Human Liver microsomes, Lane 3: Rat Liver Microsomes, Lane 4: Mouse Liver Microsomes, Lane 5: Rabbit Liver Microsomes.

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Product Literature References

Phosphodiesterase 4 mRNA Level Suppression is Important for Extract of Black Carrot to Protect Against Hepatic Injury Induced by Ethanol: A. Kitano, et al.; J. Med. Food 25, 982 (2022), Abstract;

Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice: A. Braeuning, et al.; Histochem. Cell Biol. 134, 469 (2010), Abstract;

Effect of exposure to benzo[a]pyrene on SODs, CYP1A1/1A2- and CYP2E1 immunopositive proteins in the blood clam Scapharca inaequivalvis: M. Monari, et al. ; Mar. Environ. Res. 63, 200 (2007), Application(s): WB using clam tissue, Abstract;

Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis: H. Liu, et al.; Kidney Int. 63, 1687 (2003), Abstract;

Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341: S.W. French, et al. ; Free Radic. Biol. Med. 32, 17 (2002), Application(s): WB using rat samples, Abstract;

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