| ADI-KAS-NO001-D | 50 µg | 267.00 USD |  |
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| ADI-KAS-NO001-F | 200 µg | 443.00 USD | |
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| Alternative Name: | NOS2, NOS II, Nitric oxide synthase (inducible), Hepatocyte NOS |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to aa 1131-1144 of mouse iNOS. |
| UniProt ID: | P29477 |
| Gene/Protein Identifier: | NM_010927 (RefSeq) |
| Source: | Purified from rabbit serum. |
| Species reactivity: | Mouse, Rat Bovine |
| Applications: | IP, WB |
| Recommended Dilutions/Conditions: | Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~130kDa by Western blot. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation. |
| Regulatory Status: | RUO - Research Use Only |
Brain (rat), (tissue extract) |
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| Rat brain extract, WB | Print as PDF | ||||||
| ADI-LYT-RB100-F | 200 µg | 225.00 USD | |
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Goat anti-rabbit IgG, polyclonal antibody (HRP conjugate) |
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| ELISA, IHC, WB | Print as PDF | ||||||
| ADI-SAB-300-J | 1 ml | 154.00 USD | |
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