Alternative Name: | CD117 |
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Host: | Rabbit |
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Isotype: | IgG |
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Immunogen: | Synthetic peptide for C-terminal of human c-Kit. |
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UniProt ID: | P10721 |
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Species reactivity: | Human
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Applications: | IHC (PS), WB
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Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections, 1:200) Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Purity Detail: | Protein A-affinity purified. |
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Formulation: | Liquid. In PBS containing 50% glycerol. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | c-Kit, also known as CD117 and Stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit protooncogene. c-Kit regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis, and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. |
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Regulatory Status: | RUO - Research Use Only |
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