Product Details
Alternative Name: | Signal transducer and activator of transcription 1 α |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human Stat1α. |
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UniProt ID: | P42224 |
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Species reactivity: | Human, Mouse, Rat
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Applications: | ICC, IP, WB
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Recommended Dilutions/Conditions: | Immunoprecipitation (2-4µg/sample) Western Blot (0.5µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Purity Detail: | DEAE purified. |
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Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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Shipping: | Blue Ice Not Frozen |
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Long Term Storage: | +4°C |
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Scientific Background: | Stats (Signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, Stats enter the nucleus to regulate transcription of many different genes. |
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Regulatory Status: | RUO - Research Use Only |
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Immunocytochemistry analysis of STAT1 alpha in HeLa cells with STAT1 alpha antibody at 10µg/ml.
Western blot analysis of STAT1 alpha in whole cell lysates from HeLa (H), Jurkat (J), A431 (A), K562 (K), and NIH3T3 (N) cells, with STAT1 alpha antibody at 1µg/ml.
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Product Literature References
Temporal dynamics of a CSF1R signaling gene regulatory network involved in epilepsy: C. Gérard, et al.; PLoS Comput. Biol.
17, 1008854 (2021),
Abstract;
The chemokine CCL2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal cells: J. Cho, et al. ; J. Neuroimmunol.
199, 94 (2008),
Application(s): WB using rat cell lysates,
Abstract;