Alternative Name: | Serum/glucocorticoid regulated kinase 1 |
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Host: | Rabbit |
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UniProt ID: | O00141 |
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Source: | Whole rabbit serum. |
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Species reactivity: | Human Monkey
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Applications: | IHC, WB
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Recommended Dilutions/Conditions: | Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~50-55kDa by Western blot. |
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Purity Detail: | Antiserum. |
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Formulation: | Liquid. Whole rabbit serum. |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | SGKs (Serum and glucocorticoid-inducible kinases) are serine/threonine kinases belonging to the AGC subfamily. There are 3 isoforms, SGK1, SGK2, and SGK3. SGK1 plays an important role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. |
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Regulatory Status: | RUO - Research Use Only |
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Immunohistochemistry analysis of human breast cancer section, stained with SGK-1 (CT), pAb. Overexpression is limited to DCISand invasive carcinoma.
Immunohistochemistry analysis of human hepatoma tissue with PDK1 pAb.
Western blot analysis of SGK-1 (CT), pAb: Lane 1: SGK, Lane 2: PLPCX