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PKG polyclonal antibody



ADI-KAP-PK002-D	50 µg	204.00 USD

ADI-KAP-PK002-F	200 µg	407.00 USD
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Product Specification

Alternative Name:	Protein kinase G, cGMP-dependent protein kinase 1

Host:	Rabbit

Immunogen:	Synthetic peptide corresponding to a portion of human PKG1β, with the subsitiution of a tryptophan residue for tyrosine at residue 9.

UniProt ID:	Q13976-2

GenBank ID:	Y07512

Source:	Purified from rabbit serum.

Species reactivity:	Human, Mouse, Rat Bovine

Applications:	ICC, IHC, IP, WB

Recommended Dilutions/Conditions:	Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Application Notes:	Detects a band of ~80kDa by Western blot.

Purity Detail:	Peptide affinity purified.

Formulation:	Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	Cyclic GMP-dependent protein kinases (PKGs or cGKs) are classified into two types, PKGI and PKGII. Studies have shown that PKGs are highly homologous to PKAs; phosphorylation of cellular proteins by both families of kinases leads to alterations in calcium mobilization, protein phosphatase activity, ion channel function, gene transcription, smooth muscle contractility, and platelet aggregation.

Regulatory Status:	RUO - Research Use Only

Western blot analysis of Prod. No. ADI-KAP-PK002: Lane 1: MW marker, Lane 2: HeLa cell lysate, Lane 3: Rat brain tissue extract, Lane 4: MDBK cell lysate.

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Product Literature References

The Golgi apparatus regulates cGMP-dependent protein kinase I compartmentation and proteolysis: S. Kato, et al.; Am. J. Physiol. Cell Physiol. 308, C944 (2015), Abstract; Full Text

Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle: J.M. Simard, et al. ; Circ. Res. 93, 805 (2003), Application(s): IHC, WB using rat samples, Abstract;

Protein kinase G activation of K(ATP) channels in human-cultured prostatic stromal cells: J.M. Haynes, et al. ; Cell. Signal. 14, 1023 (2002), Application(s): ICC using human samples, Abstract;

Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin: R. Pamukcu, et al. ; Cancer Res. 60, 3338 (2000), Application(s): WB using human samples, Abstract;

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