| ADI-KAP-MA112-E | 100 µg | 319.00 USD |  |
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| Alternative Name: | Eukaryotic translation initiation factor 4E-binding protein 2 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to a portion of human eIF4E-BP2. The sequence is completely conserved in mouse. |
| UniProt ID: | Q13542 |
| GenBank ID: | L36056 |
| Source: | Purified from rabbit serum. |
| Species reactivity: | Human, Mouse, Rat Bovine, Dog, Porcine, Rabbit |
| Applications: | IHC (PS), WB |
| Recommended Dilutions/Conditions: | Western Blot (4µg/ml colorimetric, 4µg/ml ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In borate buffered saline, pH 8.4, containing 25mM sodium borate, 100mM boric acid, 75mM sodium chloride, and 5mM EDTA. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The eukaryotic translation initiation factors (eIFs) regulate translation at the level of messenger RNA engagement by the ribosome. eIF-2alpha promotes the binding of the initiator tRNA to 40S ribosomal subunits, and is a key signaling component of the unfolded protein response (UPR). eIF-4E recruits mRNAs to the eIF4F complex through binding of their 5 N7-methylguanosine cap. eIF-4E binding proteins-1 and -2 are translational repressors, sequestering eIF-4E in conditions of low cellular demand for translation. Their dissociation from eIF-4E is regulated by phosphorylation in response to growth-promoting stimuli. |
| Regulatory Status: | RUO - Research Use Only |
