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MEK5 polyclonal antibody

ADI-KAP-MA003-E 100 µg 372.00 USD
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Product Details

Alternative Name:MKK5, MAP kinase kinase 5
Immunogen:Synthetic peptide corresponding to a portion of human MEK5. The sequence is completely conserved in rat.
UniProt ID:Q13163
GenBank ID:U71088
Source:Purified from rabbit serum.
Species reactivity:Human, Mouse, Rat
Dog, Monkey, Rabbit, Sheep, Xenopus
Applications:IHC, WB
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~42kDa by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:MEK is a dual specificity kinase capable of phosphorylating both tyrosine and threonine residues. The MEK family, which is also known as MAP kinase kinase, phosphorylates MAP kinases on the conserved T-X-Y motif; phosphorylation of MAPK by MEK results in an increase in MAPK activity. MEK is involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis.
Regulatory Status:RUO - Research Use Only
MEK5 polyclonal antibody Western blot
Western Blot analysis of MEK5, pAb (Prod. No. ADI-KAP-MA003): Lane 1: Jurkat, Lane 2: Mouse Testes, Lane 3: Rat Brain
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MEK5 polyclonal antibody Western blot

Product Literature References

Clinical, genetic and pharmacological data support targeting the MEK5/ERK5 module in lung cancer: A. Sánchez-Fdez, et al.; NPJ Precis. Oncol. 5, 78 (2021), Abstract;
MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion: H.Y. Leung, et al. ; Oncogene 22, 1381 (2003), Application(s): IHC using human samples, Abstract;
MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway: J.D. Lee, et al. ; J. Biol. Chem. 274, 36035 (1999), Application(s): WB using mouse samples, Abstract;

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Brain (rat), (tissue extract) 

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