Product Details
| Alternative Name: | TRP53, Tumor protein p53 |
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| Host: | Sheep |
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| Immunogen: | Recombinant human p53 (aa 1-393). |
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| UniProt ID: | P04637 |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | IHC, IP, WB
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| Recommended Dilutions/Conditions: | Western Blot (1-10µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~53kDa by Western blot. |
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| Purity Detail: | Peptide affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.08% sodium azide. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to Mdm2, SV40 T antigen and human Papilloma virus E6 protein. p53 senses DNA damage and facilitates its repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovary, bladder, colon, lung, and melanoma. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Prognostic impact and targeting of CRM1 in acute myeloid leukemia: K. Kojima, et al.; Blood
121, 4166 (2013),
Abstract;
