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[pSer⁷⁸⁰]Rb monoclonal antibody (2C4)



ADI-KAM-CP121-E	100 µg	364.00 USD
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Alternative Name:	Retinoblastoma-associated protein

Clone:	2C4

Host:	Mouse

Isotype:	IgG1

Immunogen:	Synthetic peptide corresponding to a portion of human Rb phosphorylated at Ser⁷⁸⁰.

UniProt ID:	P06400

Species reactivity:	Human

Applications:	WB

Recommended Dilutions/Conditions:	Western Blot (1µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Purity Detail:	Protein A affinity purified.

Formulation:	Lyophilized. In PBS, pH 7.2, containing 1% sucrose. No preservatives. For a stock solution of 1.0mg/ml reconstitute with 100μl of sterile distilled water.

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	The Retinoblastoma (Rb) is a tumor suppressor phosphoprotein that plays a critical role in the regulation of the cell cycle. In the absence of mitogenic signaling, Rb sequesters the transcription factor E2F within the cytosol. Upon phosphorylation, E2F is liberated from Rb and translocates to the nucleus where the latter facilitates gene transcription. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Regulatory Status:	RUO - Research Use Only