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Chk2 monoclonal antibody (DCS-270)

ADI-KAM-CC112-E 100 µg 285.00 USD
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Product Details

Alternative Name:Checkpoint kinase 2
Immunogen:Recombinant human Chk2.
UniProt ID:O96017
Species reactivity:Human
Applications:IHC, IP, WB
Recommended Dilutions/Conditions:Immunohistochemistry (1-5µg/ml)
Immunoprecipitation (3µg/200-300µl)
Western Blot (0.2µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:The DNA damage checkpoint is a signal transduction pathway that has the ability to delay entry into mitosis. When DNA is damaged, the Check point kinases (CHKs) are known to act downstream of ATM to elicit appropriate responses such as cell cycle arrest. Chk1, for instance, is activated by ATM phosphorylation of serines 123, 178, 278, and 292 of the S phase-promoting cdc25A phosphatase and accelerates IR (ionizing radiation)induced degradation of cdc25A.
Regulatory Status:RUO - Research Use Only
Chk2 monoclonal antibody (DCS-270) Immunoprecipitation
Immunoprecipitation analysis of Chk2 from HeLa cells with normal mouse IgG (1) or K0087 -3 (2). After immunoprecipitated with the antibody, immunocomplex was resolved on SDS -PAGE and immunoBlotted with Chk2 mAb (DCS-270).
Chk2 monoclonal antibody (DCS-270) Immunohistochemistry
Immunohistochemistry analysis of paraffin-embedded human intestine stained with Chk2 Monoclonal Antibody (DCS-270).
Chk2 monoclonal antibody (DCS-270) Western blot
Western blot analysis of HeLa cells (1), NIH/3T3 cells (2) and Rat-1 cells (3) using Chk2 mAb (DCS - 270)
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Chk2 monoclonal antibody (DCS-270) Immunoprecipitation Chk2 monoclonal antibody (DCS-270) Immunohistochemistry Chk2 monoclonal antibody (DCS-270) Western blot

Product Literature References

A high-throughput pipeline for validation of antibodies: K. Sikorski, et al.; Nat. Methods 15, 909 (2018), Abstract;

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