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Plk1 monoclonal antibody (3F8)

ADI-KAM-CC105-D 50 µg 243.00 USD
ADI-KAM-CC105-F 200 µg 501.00 USD
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Product Details

Alternative Name:Polo-like kinase 1
Immunogen:Recombinant fragment from the middle of human PLK1.
UniProt ID:P53350
Source:Purified from hybridoma tissue culture supernatant.
Species reactivity:Human, Rat
Crossreactivity:Weakly cross-reacts with mouse Plk1.
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~62kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:The polo-like kinases (PLKs) function in cell-cycle progression and in multiple stages of mitosis. PLK1 is activated by phosphorylation of Thr210 at the G2/M phase boundary. Active PLK1 participates in mitotic entry through activation of Cdc25C and nuclear import of cyclin B1, thereby activating the Cdc2/cyclin B kinase.
Regulatory Status:RUO - Research Use Only
Plk1 monoclonal antibody (3F8) Western blot
Western blot analysis of PLK1 mAb (3F8): Lane 1: MW marker, Lane 2: HeLa, Lane 3: Jurkat, Lane 4: PC-12, Lane 5: 3T3, Lane 6: HEK-293.
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Plk1 monoclonal antibody (3F8) Western blot

Product Literature References

Skp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry: A.C. Burrows, et al.; J. Biol. Chem. 287, 39021 (2012), Application(s): Western blot, Abstract; Full Text

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