Product Specification
Alternative Name: | Protein kinase C inhibitor protein, Protein 1054 |
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Clone: | 22-ii-D8B |
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Host: | Mouse |
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Isotype: | IgG |
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Immunogen: | Lysed transformed human amnion cells (AMA). |
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UniProt ID: | P31946 (14-3-3 beta), P63104 (14-3-3 zeta) |
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Gene/Protein Identifier: | NP_003395 (RefSeq of 14-3-3 beta), NP_663723 (RefSeq of 14-3-3 zeta) |
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Source: | Purified from mouse ascites. |
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Species reactivity: | Human, Mouse, Rat Bovine, Dog, Monkey, Porcine, Rabbit, Sheep
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Applications: | ICC, IHC, WB
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Recommended Dilutions/Conditions: | Western Blot (1µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Purity Detail: | Protein G affinity purified. |
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Formulation: | Liquid. In PBS, pH 7.2, containing 0.1mM PMSF, 50% glycerol, and 0.09% sodium azide. |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | 14-3-3 proteins are highly conserved proteins that play a role in both signal transduction and progression through the cell cycle by binding to and regulating a number of different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2: W. Wasco, et al. ; J. Biol. Chem.
276, 19197 (2001),
Application(s): WB using monkey samples,
Abstract;