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14-3-3 β/ζ monoclonal antibody (22-ii-D8B)



ADI-KAM-CC012-E	100 µg	295.00 USD
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Product Specification

Alternative Name:	Protein kinase C inhibitor protein, Protein 1054

Clone:	22-ii-D8B

Host:	Mouse

Isotype:	IgG

Immunogen:	Lysed transformed human amnion cells (AMA).

UniProt ID:	P31946 (14-3-3 beta), P63104 (14-3-3 zeta)

Gene/Protein Identifier:	NP_003395 (RefSeq of 14-3-3 beta), NP_663723 (RefSeq of 14-3-3 zeta)

Source:	Purified from mouse ascites.

Species reactivity:	Human, Mouse, Rat Bovine, Dog, Monkey, Porcine, Rabbit, Sheep

Applications:	ICC, IHC, WB

Recommended Dilutions/Conditions:	Western Blot (1µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Purity Detail:	Protein G affinity purified.

Formulation:	Liquid. In PBS, pH 7.2, containing 0.1mM PMSF, 50% glycerol, and 0.09% sodium azide.

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	14-3-3 proteins are highly conserved proteins that play a role in both signal transduction and progression through the cell cycle by binding to and regulating a number of different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms.

Regulatory Status:	RUO - Research Use Only

14-3-3 β/ζ monoclonal antibody (22-ii-D8B) Western blot

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Product Literature References

Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2: W. Wasco, et al. ; J. Biol. Chem. 276, 19197 (2001), Application(s): WB using monkey samples, Abstract;