| ADI-EKS-450 | 30 tests | 1,676.00 USD |  |
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| Do you need bulk/larger quantities? | |||||
| Applications: | WB Activity assay, GST pulldown |
| Application Notes: | For the measurement of active Rac1 in cell lysates of human, mouse, rat, dog, and chicken origin. |
| Species reactivity: | Human, Mouse, Rat Chicken, Dog |
| Use/Stability: | Reagents require separate storage conditions upon receipt. |
| Shipping: | Shipped on Blue Ice |
| Contents: | Glutathione Resin, 2X SDS Sample Buffer, 1X Lysis/Binding/Wash Buffer, Antibody, GST-Pak1-PBD, 100X GDP, 100X GTP, Spin Cups, Collection Tubes |
| Scientific Background: | Rac, cdc42 and the Rho subfamilies belong to the Rho-family of small GTP-binding proteins (G proteins or GTPases), which have been implicated in regulating a variety of cellular functions including actin cytoskeleton organization, cell growth control and development, transcriptional activation, membrane trafficking, and cell transformation. Cdc42/Rac are important upstream regulators of the protein kinase cascade that controls the SAPK/Jnk and p38 activity. Like all small GTPases, Rac acts as a switch regulating molecular events by cycling between an inactive GDP-bound state and an active GTP-bound state. |
| UniProt ID: | P63000 |
| Regulatory Status: | RUO - Research Use Only |
