Product Specification
| Alternative Name: | TPN, TPSN, TAP binding protein |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to aa 2-20 of human tapasin with a cysteine residue added. |
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| UniProt ID: | O15533 |
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| GenBank ID: | AF009510 |
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| Source: | Whole rabbit serum. |
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| Species reactivity: | Human
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~48kDa by Western blot. |
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| Formulation: | Liquid. Whole Rabbit Serum. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Tapasin is a 48 kDa glycoprotein which is a member of the immunoglobulin superfamily and is required for efficient peptide binding to TAP (Transporter associated with antigen processing). TAP binds peptides in its cytosolic part and subsequently translocates the peptides into the lumen of the endoplasmic reticulum where assembly of MHC class I and peptide takes place. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of Tapasin: Lane 1: MW Marker, Lane 2: HeLa Cell Lysate, Lane 3: A431 Cell Lysate.
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Product Literature References
HLA-G peptide preferences change in transformed cells: impact on the binding motif: A.A. Celik, et al.; Immunogenetics
70, 485 (2018),
Abstract;
Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes: S. Badrinath, et al.; Haematologica
97, 98 (2012),
Abstract;
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