Product Details
Alternative Name: | Transporter Associated with Antigen Processing 1 |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to a portion of human TAP1 . |
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UniProt ID: | Q03518 |
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Source: | Purified from rabbit serum. |
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Species reactivity: | Human, Rat
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Applications: | IHC (PS), IP, WB
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Recommended Dilutions/Conditions: | Immunoprecipitation (1:100) Western Blot (ECL, 1:1,000-1:4000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~70kDa by Western blot. |
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Formulation: | Liquid. Whole rabbit serum. |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | TAP1 and TAP2 are two structurally related subunits of the Transporter associated with antigen processing (TAP). The TAP complex is a member of the ATP binding cassette (ABC) family of transmembrane transporters. The TAP transporter is an essential component of the MHC class I antigen presentation pathway by binding peptides in its cytosolic part and subsequently translocating the peptides into the lumen of the endoplasmic reticulum where assembly of MHC class I and pepide takes place. |
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Regulatory Status: | RUO - Research Use Only |
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IHC Analysis: Human uterus tissue stained with TAP1, pAb at 1:100.
IHC Analysis: Human prostate tissue stained with TAP1, pAb at 1:100.
IHC Analysis: Human tonsil tissue stained with TAP1, pAb at 1:100.
Western blot analysis of TAP1, pAb (Prod. No. ADI-CSA-620): Lane 1: MW marker, Lane 2: A431 cell lysate Lane 3: HeLa cell lysate (Prod. No. ADI-LYC-HL100)
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Product Literature References
Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors: K. Hirabayashi, et al.; Anticancer Res.
38, 2227 (2018),
Abstract;
HLA-G peptide preferences change in transformed cells: impact on the binding motif: A.A. Celik, et al.; Immunogenetics
70, 485 (2018),
Abstract;
WT1-pulsed Dendritic Cell Vaccine Combined with Chemotherapy for Resected Pancreatic Cancer in a Phase I Study: R. Yanagisawa, et al.; Anticancer Res.
38, 2217 (2018),
Abstract;
Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer: T. Shen, et al.; Oncotarget
8, 60975 (2017),
Abstract;
Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes: S. Badrinath, et al.; Haematologica
97, 98 (2012),
Abstract;
Full Text
MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding: P. Cresswell, et al. ; Nature
368, 864 (1994),
Application(s): IP using human samples,
Abstract;
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