Product Details
| Alternative Name: | Myeloid differentiation primary response gene |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to a portion of human MyD88. The sequence is completely conserved in mouse. |
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| UniProt ID: | Q99836 |
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| GenBank ID: | NM_002468.1 (RefSeq) |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (1-2µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~35kDa by Western blot. |
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| Purity Detail: | Peptide affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | MyD88 (Myeloid differentiation primary response gene 88) is a general adapter protein for the Toll/IL-1R family of receptors that have been shown to induce growth arrest, terminal differentiation, and apoptosis. MyD88 plays an important role in the inflammatory response induced by cytokines, IL-1 and IL-18, and endotoxin. It has been shown that signaling via MyD88 is essential for an LPS response. MyD88 is a cytoplasmic protein, which is expressed in many tissues. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of MyD88 in Jurkat whole cell lysate with MyD88 antibody at 1:500 dilution.
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Product Literature References
IRAK-M is a negative regulator of Toll-like receptor signaling: R.A. Flavell, et al. ; Cell
110, 191 (2002),
Application(s): WB using mouse samples,
Abstract;
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