| ADI-CSA-507-E | 100 µg | 458.00 USD |  |
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| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of human CIKS. |
| UniProt ID: | O43734 |
| Species reactivity: | Human |
| Applications: | IHC, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (5µg/ml) Western Blot (0.5-1.0µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~63kDa by Western blot. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | +4°C |
| Scientific Background: | NF-κB is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB associates with IkappaB proteins in the cell cytoplasm, which inhibit its activity. IkappaB is phosphorylated by IkappaB kinase (IKK) complex that contains IKKalpha, IKKbeta, and IKKgamma. CIKS (connection to IKK and SAPK/Jnk) or Act1 (NF-κB activator) associates with and activates IKK. CIKS/Act1 also activates the activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (Jnk). |
| Regulatory Status: | RUO - Research Use Only |
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