Product Details
| Alternative Name: | Cyclooxygenase 2, Prostaglandin H synthase 2 |
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| Clone: | AS73 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant human COX-2 (cyclooxygenase-2). |
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| UniProt ID: | P35354 |
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| Species reactivity: | Rat
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| Applications: | ELISA
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.08% sodium azide. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Cyclooxygenases-1 and 2 (COX-1 and COX-2) also known as Prostaglandin endoperoxide H synthases-1 and 2 are integral membrane proteins which catalyze the first step of Prostaglandin, Thromboxane, and Procastacyclin production from Arachidonic acid. The COX-1 and COX-2 enzymes are important pharmacologically as targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, ibuprofen and the COX-2 inhibitors. Inhibition of Cyclooxygenases with NSAIDs acutely reduces inflammation, pain, and fever. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The contribution of hypothalamic neuroendocrine, neuroplastic and neuroinflammatory processes to lipopolysaccharide-induced depressive-like behaviour in female and male rats: Involvement of glucocorticoid receptor and C/EBP-β: M. Adzic, et al.; Behav. Brain Res.
291, 130 (2015),
Application(s): Western Blot,
Abstract;
