| ADI-AAP-465-E | 100 µl | 230.00 USD |  |
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| Alternative Name: | Second mitochondria-derived activator of caspase |
| Host: | Rabbit |
| Immunogen: | Recombinant human Smac/DIABLO . |
| UniProt ID: | Q9NR28 |
| Gene/Protein Identifier: | NM_019887 (RefSeq) |
| Species reactivity: | Human, Mouse, Rat Hamster |
| Applications: | WB |
| Recommended Dilutions/Conditions: | Western Blot (1-2µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate. |
| Regulatory Status: | RUO - Research Use Only |
HeLa, (cell lysate) |
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| Human, WB | Print as PDF | ||||||
| ADI-LYC-HL100-F | 200 µg | 119.00 USD | |
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