Alternative Name: | Second mitochondria-derived activator of caspase |
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Host: | Rabbit |
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Immunogen: | Recombinant human Smac/DIABLO . |
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UniProt ID: | Q9NR28 |
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Gene/Protein Identifier: | NM_019887 (RefSeq) |
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Species reactivity: | Human, Mouse, Rat Hamster
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Applications: | WB
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Recommended Dilutions/Conditions: | Western Blot (1-2µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Purity Detail: | Protein G affinity purified. |
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Formulation: | Liquid. In PBS containing 50% glycerol. |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate. |
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Regulatory Status: | RUO - Research Use Only |
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