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c-FLIP polyclonal antibody

ADI-AAP-440-E 100 µg 392.00 USD
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Product Details

Alternative Name:CASPER, CLARP, I-FLICE, Usurpin
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human c-FLIP6. The sequence conserved among all c-FLIP variants.
UniProt ID:O15519
GenBank ID:U97074, U97075
Species reactivity:Human, Mouse, Rat
Applications:ICC, WB
Recommended Dilutions/Conditions:Immunocytochemistry (5µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~28-58kDa by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:-20°C
Scientific Background:The cellular FLICE-like inhibitory protein, cFLIP, is a cellular homologue of the viral protein, vFLIP. cFLIP contains two death effector domains (DEDs) and is expressed as either a short or long splice variant called cFLIPs and cFLIPL, respectively. cFLIP acts as a caspase-8 dominant negative regulator, blocking apoptosis induced by the oligimerization of the adapter protein, FADD. cFLIP interacts with FADD and caspase-8 through their respective DEDs.
Regulatory Status:RUO - Research Use Only
c-FLIP polyclonal antibody Immunocytochemistry
Immunocytochemistry analysis of FLIP in HeLa cells with FLIP antibody at 5µg/ml.
c-FLIP polyclonal antibody Western blot
Western blot analysis of FLIP in K562 cell lysate with FLIP antibody at (A) 1 and (B) 2µg/ml.
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c-FLIP polyclonal antibody Immunocytochemistry c-FLIP polyclonal antibody Western blot

Product Literature References

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation: G. Liccardi, et al.; Mol. Cell 73, 413 (2019), Abstract; Full Text
Codium fragile F2 sensitize colorectal cancer cells to TRAIL-induced apoptosis via c-FLIP ubiquitination: S.H. Park, et al.; Biochem. Biophys. Res. Commun. 508, 1 (2018), Abstract;
Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells: J.M. Yun, et al.; Molecules 23, E2264 (2018), Abstract; Full Text
Ophiopogonin B sensitizes TRAIL-induced apoptosis through activation of autophagy flux and downregulates cellular FLICE-like inhibitory protein: U.M. Nazim, et al.; Oncotarget 9, 4161 (2017), Abstract; Full Text
The coffee diterpene kahweol enhances sensitivity to sorafenib in human renal carcinoma Caki cells through down-regulation of Mcl-1 and c-FLIP expression: K.J. Min, et al.; Oncotarget. 8, 83195 (2017), Abstract; Full Text
5 Fluorouracil Preferentially Sensitizes Mutant KRAS Non-Small Cell Lung Carcinoma Cells to TRAIL-Induced Apoptosis: H. Wang, et al.; Mol. Oncol. 9, 1815 (2015), Application(s): Western Blot, Abstract; Full Text
Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells: S. Seah, et al.; Cell Death Dis. 6, e1926 (2015), Application(s): Western Blot, Abstract; Full Text
Protective effect of RIP and c-FLIP in preventing liver cancer cell apoptosis induced by TRAIL: J. Sun, et al.; Int. J. Clin. Exp. Pathol. 8, 6519 (2015), Application(s): Western blot , Abstract; Full Text

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