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c-FLIP polyclonal antibody

ADI-AAP-440-E 100 µg 431.00 USD
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Product Details

Alternative Name:CASPER, CLARP, I-FLICE, Usurpin
Immunogen:FLIP antibody was raised against a peptide corresponding to 17 amino acids near the amino terminus of human FLIP. The sequence is identical in all FLIP splice variants. The immunogen is located within the first 50 amino acids of FLIP.
UniProt ID:O15519
GenBank ID:U97074, U97075
Species reactivity:Human, Mouse, Rat
Applications:ICC, WB
Recommended Dilutions/Conditions:Immunocytochemistry (5µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~28-58kDa by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:-20°C
Scientific Background:The cellular FLICE-like inhibitory protein, cFLIP, is a cellular homologue of the viral protein, vFLIP. cFLIP contains two death effector domains (DEDs) and is expressed as either a short or long splice variant called cFLIPs and cFLIPL, respectively. cFLIP acts as a caspase-8 dominant negative regulator, blocking apoptosis induced by the oligimerization of the adapter protein, FADD. cFLIP interacts with FADD and caspase-8 through their respective DEDs.
Regulatory Status:RUO - Research Use Only
c-FLIP polyclonal antibody Immunocytochemistry
Immunocytochemistry analysis of FLIP in HeLa cells with FLIP antibody at 5µg/ml.
c-FLIP polyclonal antibody Western blot
Western blot analysis of FLIP in K562 cell lysate with FLIP antibody at (A) 1 and (B) 2µg/ml.
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c-FLIP polyclonal antibody Immunocytochemistry c-FLIP polyclonal antibody Western blot

Product Literature References

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation: G. Liccardi, et al.; Mol. Cell 73, 413 (2019), Abstract; Full Text
Codium fragile F2 sensitize colorectal cancer cells to TRAIL-induced apoptosis via c-FLIP ubiquitination: S.H. Park, et al.; Biochem. Biophys. Res. Commun. 508, 1 (2018), Abstract;
Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells: J.M. Yun, et al.; Molecules 23, E2264 (2018), Abstract; Full Text
Ophiopogonin B sensitizes TRAIL-induced apoptosis through activation of autophagy flux and downregulates cellular FLICE-like inhibitory protein: U.M. Nazim, et al.; Oncotarget 9, 4161 (2017), Abstract; Full Text
The coffee diterpene kahweol enhances sensitivity to sorafenib in human renal carcinoma Caki cells through down-regulation of Mcl-1 and c-FLIP expression: K.J. Min, et al.; Oncotarget. 8, 83195 (2017), Abstract; Full Text
5 Fluorouracil Preferentially Sensitizes Mutant KRAS Non-Small Cell Lung Carcinoma Cells to TRAIL-Induced Apoptosis: H. Wang, et al.; Mol. Oncol. 9, 1815 (2015), Application(s): Western Blot, Abstract; Full Text
Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells: S. Seah, et al.; Cell Death Dis. 6, e1926 (2015), Application(s): Western Blot, Abstract; Full Text
Protective effect of RIP and c-FLIP in preventing liver cancer cell apoptosis induced by TRAIL: J. Sun, et al.; Int. J. Clin. Exp. Pathol. 8, 6519 (2015), Application(s): Western blot , Abstract; Full Text

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