| ADI-AAP-371-E | 100 µg | 481.00 USD |  |
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| Alternative Name: | TRAIL receptor 4, DcR2, Death Receptor 2, TRUNDD, CD264, TNFRSF 10D, TNFRSF 10D, TNF-related apoptosis-inducing ligand receptor 4, Tumor necrosis factor receptor superfamily member 10D |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to a portion of human TRAIL-R4. |
| UniProt ID: | Q9UBN6 |
| GenBank ID: | AF029761 |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | ICC, IHC, WB |
| Recommended Dilutions/Conditions: | Immunocytochemistry (10µg/ml) Western Blot (1:1,000-1:2,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~36kDa by Western blot. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Decoy receptors (DcRs) are signaling-deficient receptors for certain members of the TNF family of cytokines, including TRAIL/Apo2L and FasL. Functional TRAIL receptors such as DR4 and DR5 transmit apoptotic signals via their intracellular death domains. In contrast, three identified TRAIL decoy receptors (DcR1, DcR2, and osteoprotegerin/OPG) completely or partially lack the signaling death domain, and/or are secreted from cells and unable to transmit intracellular signals. Thus, expression of DcRs promotes survival by sequestration of apoptotic ligands. A fourth identified decoy receptor, DcR3, binds both FasL and the vascular endothelial cell growth inhibitor (VEGI), inhibiting Fas and DR3 death signals. |
| Regulatory Status: | RUO - Research Use Only |
