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AIF (IN) polyclonal antibody

ADI-AAP-015-E 100 µg 386.00 USD
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Product Details

Alternative Name:Apoptosis-inducing factor
Immunogen:Synthetic peptide corresponding to a portion of human AIF .
UniProt ID:O95831
GenBank ID:AAD16436
Species reactivity:Human, Mouse, Rat
Recommended Dilutions/Conditions:Western Blot (0.25-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~67kDa by Western blot.
Purity Detail:Ion exchange purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:Apoptosis inducing factor (AIF) is a mitochondrial inter-membrane flavoprotein that is ubiquitously expressed both in normal tissues and in a variety of cancer cell lines. AIF is synthesized as a nonapoptogenic precursor in the cytoplasm and efficiently imported into the mitochondrial inter-membrane space. Mature AIF protein is normally confined to the mitochondrial inter-membrane space. In a variety of different apoptosis-inducing conditions AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus. Extra-mitochondrial AIF induces nuclear chromatin condensation and large scale (~50kb) DNA fragmentation.
Regulatory Status:RUO - Research Use Only
AIF (IN) polyclonal antibody Western blot
Western blot analysis of human K562 cell lysates (A), rat (B), and mouse (C) heart tissue using AIF (IN) pAb at 1µg/ml.
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AIF (IN) polyclonal antibody Western blot

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Apoptosis-inducing factor
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Apoptosis-inducing factor Polyclonal antibody
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