| ADI-AAP-015-E | 100 µg | 386.00 USD |  |
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| Alternative Name: | Apoptosis-inducing factor |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to a portion of human AIF . |
| UniProt ID: | O95831 |
| GenBank ID: | AAD16436 |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | WB |
| Recommended Dilutions/Conditions: | Western Blot (0.25-1.0µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~67kDa by Western blot. |
| Purity Detail: | Ion exchange purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | +4°C |
| Scientific Background: | Apoptosis inducing factor (AIF) is a mitochondrial inter-membrane flavoprotein that is ubiquitously expressed both in normal tissues and in a variety of cancer cell lines. AIF is synthesized as a nonapoptogenic precursor in the cytoplasm and efficiently imported into the mitochondrial inter-membrane space. Mature AIF protein is normally confined to the mitochondrial inter-membrane space. In a variety of different apoptosis-inducing conditions AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus. Extra-mitochondrial AIF induces nuclear chromatin condensation and large scale (~50kb) DNA fragmentation. |
| Regulatory Status: | RUO - Research Use Only |
