| Alternative Name: | Bcl-2 associated athanogene-1, BAG family molecular chaperone regulator 1, RAP46 |
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| Clone: | 4A2 |
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| Host: | Mouse |
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| Isotype: | IgG |
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| Immunogen: | Recombinant mouse Bag-1. |
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| UniProt ID: | Q60739 |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~28kDa (mouse and rat), ~31kDa (human) by Western blot. |
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Bag-1 is a multifunctional Bcl-2-binding protein that lacks sequence homology with Bcl-2 and its related proteins, and functions to enhance the anti-apoptotic effects of Bcl-2. Bag-1 binds to the intracellular domain of the hepatocyte growth factor (HGF) and platelet-derived growth factor (PDGF) receptors, enhancing growth factor mediated protection from apoptosis. Bag-1 is known to modulate the chaperone activity of Hsc70/Hsp70, serving as a nucleotide exchange factor via binding to the ATPase domain of Hsc70/Hsp70. Bag-1 is known to promote cell survival through activation of the Raf-1 kinase. |
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| Regulatory Status: | RUO - Research Use Only |
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