| ADI-AAM-382-E | 100 µg | 336.00 USD |  |
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| Alternative Name: | CAD |
| Clone: | 6B8 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human DFF45. |
| UniProt ID: | O00273 |
| Species reactivity: | Human |
| Applications: | WB |
| Recommended Dilutions/Conditions: | Western Blot (1µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~45kDa (DFF45/ICAD-L) and ~40kDa (DFF45/ICAD-S) by Western blot. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Lyophilized. In PBS, pH 7.2, containing 1% sucrose. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Human DNA fragmentation fragment (DFF) 45 and its mouse homologue caspase activated deoxyribonuclease (ICAD) are the inhibitors of DFF40 and CAD, respectively. DFF is composed of two subunits, DFF40/CAD and DFF45/ICAD. Cleavage of DFF45/ICAD, which is mediated by caspase-3, leads to DFF40/CADs activation as a nuclease. Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death. DFF40 mRNA is expressed in a limited number of human tissues; pancreas, spleen, prostate, and ovary. |
| Regulatory Status: | RUO - Research Use Only |
HeLa, (cell lysate) |
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| Human, WB | Print as PDF | ||||||
| ADI-LYC-HL100-F | 200 µg | 137.00 USD | |
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