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Caspase-4 monoclonal antibody (4B9)

ADI-AAM-114-E 100 µg 422.00 USD
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Product Details

Immunogen:Recombinant human caspase-4 (N-terminal fragment).
UniProt ID:P49662
GenBank ID:HSU28014
Species reactivity:Human
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~45kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.
Regulatory Status:RUO - Research Use Only
Caspase-4 monoclonal antibody (4B9) Western blot
Western blot analysis of caspase-4 probed with Caspase-4, mAb (4B9). Lane 1: TXp20 (recombinant); Lane 2: U937 cell extract; Lane 3: HL60 cell extract; Lane 4: HUC-Fm cell extract; Lane 5: PC12 cell extract.
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Caspase-4 monoclonal antibody (4B9) Western blot

Product Literature References

Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents Burkholderia thailandensis-Induced Multinucleated Giant Cell Formation: M. Dilucca, et al.; Mbio 12, e0205421 (2021), Abstract;
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection: G. Luchetti, et al.; Cell Host Microbe 193, 386 (2021), Abstract;
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signaling: N. Kayagaki, et al.; Nature 526, 666 (2015), Application(s): Pyroptosis of innate human immune cells, Abstract;
GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses: Y. Hotokezaka, et al.; Cell Death Dis. 6, e1719 (2015), Abstract; Full Text
Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer: J.S. Carew, et al.; Cell Death Dis. 4, e728 (2013), Abstract; Full Text

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