| ADI-AAM-020-E | 100 µg | 393.00 USD |  |
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| Alternative Name: | OPG, TNFRSF 11B, Osteoclastogenesis inhibitory factor |
| Clone: | 98A1071 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of human OPG (osteoprotegerin). |
| UniProt ID: | O00300 |
| Species reactivity: | Human |
| Applications: | WB |
| Recommended Dilutions/Conditions: | Western Blot (1µg/ml AP, 1µg/ml ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~55kDa & ~110kDa by Western blot. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Osteoprotegerin (OPG) is a secreted glycoprotein belonging to the TNF receptor (TNF-R) superfamily that functions as a decoy receptor for RANK-Ligand (RANKL/OPGL). Unlike other TNF-Rs, OPG lacks a membrane-anchoring hydrophobic domain and lacks any apparent cell-associated signaling capability. OPG secreted by osteoblasts competes with RANK (expressed on osteoblast precursors) for binding to RANKL, blocking osteoclastogenesis and increasing bone density. |
| Regulatory Status: | RUO - Research Use Only |
