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PIP2 monoclonal antibody (KT10)

ADI-915-062-100 100 µg 426.00 USD
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Product Details

Alternative Name:Phosphatidylinositol 4,5-bisphosphate, PtdIns(4,5)P2
Immunogen:Native PIP2 from bovine spinal cord.
Source:Purified from mouse ascites.
Species reactivity:Species independent
Applications:ELISA, ICC
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS containing 0.05% sodium azide.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Metabolism of inositol phospholipids by intracellular signaling mediators is fundamental to signal transduction in eukaryotic cells. PI-4,5-P2 (Phosphatidylinositol 4,5-bisphosphate; PIP2) can be synthesized by phosphorylation of PI-4-P by type I phosphatidylinositol phosphate kinase (PIP5K I), or phosphorylation of PI-5-P by type II PIPK (PIP4K II). PI-4,5-P2 regulation of cellular calcium levels involves its hydrolysis by Phospholipase C (PLC) to produce inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), which serve as second messengers in the import of calcium via IP3-sensitive ion channels and in the activation of PKC, respectively.
Regulatory Status:RUO - Research Use Only

Product Literature References

An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis: W. Zhong, et al.; Nat. Commun. 13, 4390 (2022), Abstract;
Distribution profile of inositol 1,4,5-trisphosphate receptor/Ca2+ channels in α and β cells of pancreas: dominant localization in secretory granules and common error in identification of secretory granule membranes: Y.S. Hur, et al.; Pancreas 44, 158 (2015), Abstract;
MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development: X.H. Xu, et al.; Cell. Res. 24, 576 (2014), Application(s): Immunofluorescence, Abstract;
Phosphatidylinositol 4,5-bisphosphate alters the number of attachment sites between ezrin and actin filaments: a colloidal probe study: J.A. Braunger, et al.; J. Biol. Chem. 289, 9833 (2014), Application(s): Immunofluorescence, Abstract;
PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein: P.J. Hamilton, et al.; Nat. Chem. Biol. 10, 582 (2014), Application(s): Immunoprecipitation, Abstract; Full Text
PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker: A.A. Rodriguez-Menchaca, et al.; PNAS 109, E2399 (2012), Abstract; Full Text

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