| Alternative Name: | 15-deoxy-Δ12,14-Prostaglandin J2 |
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| Host: | Rabbit |
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| Immunogen: | 15-deoxy-Δ12,14-Prostaglandin J2. |
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| Source: | Purified from rabbit serum. |
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| Species reactivity: | Species independent
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| Applications: | ELISA
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| Purity Detail: | Sodium sulfate precipitation purified. |
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| Formulation: | Liquid. In PBS containing 1.0mg/ml Rabbit IgG and 0.1% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | 15-deoxy-Δ12,14-Prostaglandin J2 (15-d-PGJ2) is one of the ultimate dehydration products of PGD2, formed via the intermediate Δ12-PGJ2. 15-d-PGJ2 is physiologically present in body fluids at concentration of 10-12 to 10-9 M, but increases dramatically under stress such as infection and inflammation. 15-d-PGJ2 exerts both pro- and anti-inflammatory effects in a cell-type and concentration-dependent manner, with many of these effects mediated via binding to the γ isoform of the peroxisome proliferators-activated receptor (PPAR-γ). 15-d-PGJ2 appears to induce HO-1 expression by a PPAR-γ-independent mechanism mediated by the generation of reactive oxygen species (ROS). |
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| Regulatory Status: | RUO - Research Use Only |
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