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15-deoxy-Δ12,14-PGJ2 polyclonal antibody

ADI-915-043-100 100 µl 435.00 USD
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Product Details

Alternative Name:15-deoxy-Δ12,14-Prostaglandin J2
Immunogen:15-deoxy-Δ12,14-PGJ2 conjugated to a protein carrier molecule.
Source:Purified from rabbit serum.
Species reactivity:Species independent
Purity Detail:Sodium sulfate precipitation purified.
Formulation:Liquid. In PBS containing 1.0mg/ml Rabbit IgG and 0.1% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:15-deoxy-Δ12,14-Prostaglandin J2 (15-d-PGJ2) is one of the ultimate dehydration products of PGD2, formed via the intermediate Δ12-PGJ2. 15-d-PGJ2 is physiologically present in body fluids at concentration of 10-12 to 10-9 M, but increases dramatically under stress such as infection and inflammation. 15-d-PGJ2 exerts both pro- and anti-inflammatory effects in a cell-type and concentration-dependent manner, with many of these effects mediated via binding to the γ isoform of the peroxisome proliferators-activated receptor (PPAR-γ). 15-d-PGJ2 appears to induce HO-1 expression by a PPAR-γ-independent mechanism mediated by the generation of reactive oxygen species (ROS).
Regulatory Status:RUO - Research Use Only

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Prostaglandin J2
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Prostaglandin J2 Polyclonal antibody
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