Alternative Name: | MPO |
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Host: | Rabbit |
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Immunogen: | human Neutrophil Myeloperoxidase. |
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UniProt ID: | P05164 |
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Source: | Purified from rabbit serum. |
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Species reactivity: | Human
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Applications: | ELISA, WB
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Recommended Dilutions/Conditions: | ELISA (>1:3,500) Western Blot (1:3,500) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Purity Detail: | Ion exchange purified. |
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Formulation: | Liquid. In PBS containing 0.1% sodium azide. Concentration 1mg/ml. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Myeloperoxidase (MPO) is synthesized as a single chain precursor, which is then processed into a tetramer consisting of 2 light chains and 2 heavy chains. In response to microbial invasion, MPO is released from the cytoplasmic granules of neutrophils into the extracellular space and phagosome, where it generates hypohalous acids that have a strong microbicidal effect. Myeloperoxidase can be used as a marker of airway inflammation caused either by disease, such as asthma, or by environmental irritants. |
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Regulatory Status: | RUO - Research Use Only |
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