- Fast homogenous assay
- Suitable for High Throughput Screening
- Monitor multiple time points to follow kinetics
- Results in 30 to 60 minutes
The Myeloperoxidase fluorometric detection kit is a one-step no wash homogeneous activity assay that is adaptable to HTS applications. This kit offers highly sensitive fluorescent detection and the ability to monitor multiple time points to follow the kinetics of MPO activity.
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Product Details
| Alternative Name: | MPO |
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| Sensitivity: | 0.00195 units/ml |
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| Applications: | Fluorescence microscopy
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| Application Notes: | For the measurement of Myeloperoxidase activity in cells and tissue from any species. |
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| Species reactivity: | Species independent
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Contents: | Assay buffer concentrate, Detection Reagent, Hydrogen peroxide, Myeloperoxidase enzyme |
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| Scientific Background: | Myeloperoxidase (MPO) is synthesized as a single chain precursor, which is then processed into a tetramer consisting of 2 light chains and 2 heavy chains. In response to microbial invasion, MPO is released from the cytoplasmic granules of neutrophils into the extracellular space and phagosome, where it generates hypohalous acids that have a strong microbicidal effect. Myeloperoxidase can be used as a marker of airway inflammation caused either by disease, such as asthma, or by environmental irritants. |
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| UniProt ID: | P05164 |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Recombinant thrombomodulin prevents acute lung injury induced by renal ischemia-reperfusion injury: N. Hayase, et al.; Sci. Rep.
10, 289 (2020),
Abstract;
Full Text
Cystathionine-gamma-lyase deficient mice are protected against the development of multiorgan failure and exhibit reduced inflammatory response during burn: A. Ahmad, et al.; Burns
43, 1021 (2017),
Abstract;
Intraluminal tranexamic acid inhibits intestinal sheddases and mitigates gut and lung injury and inflammation in a rodent model of hemorrhagic shock: Z. Peng, et al.; J. Trauma Acute Care Surg.
81, 358 (2016),
Abstract;
Full Text
Cepharanthine mitigates lung injury in lower limb ischemia–reperfusion: M.C. Kao, et al.; J. Surg. Res.
199, 647 (2015),
Application(s): Activity detected in lung tissue in rats,
Abstract;
Cepharanthine mitigates pro-inflammatory cytokine response in lung injury induced by hemorrhagic shock/resuscitation in rats: M.C. Kao, et al.; Cytokine
76, 442 (2015),
Application(s): Activity detected in lung tissue in rats,
Abstract;
Protection by enteral glutamine is mediated by intestinal epithelial cell peroxisome proliferator-activated receptor-γ during intestinal ischemia/reperfusion: Z. Peng, et al.; Shock
43, 327 (2015),
Abstract;
Full Text
Molecular composition of the alveolar lining fluid in the aging lung: J.I. Moliva, et al.; Age
36, 9633 (2014),
Abstract;
Full Text
Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan 1: Z. Peng, et al.; Shock
40, 195 (2013),
Abstract;
Full Text
Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury: N. Cho, et al.; J. Neuroinflammation
9, 134 (2012),
Application(s): Activity detected in mouse spinal cord extracts,
Abstract;
Full Text
Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury: P. Mukhopadhyay, et al.; Free Radic. Biol. Med.
50, 179 (2011),
Application(s): Activity detected in mouse myocardial tissue extracts,
Abstract;
