- Fast - results in less than 2 hours from up to 40 samples in duplicate
- Flexible - evaluate COX-1 and/or COX-2 inhibitors
- Precise - intra-assay variation < 7%
The COX activity kit is the first commercially available non-radioactive COX activity assay. This kit lets you easily evaluate COX I and COX II inhibitors in a convenient 96-well plate based assay with < 7% intra-assay variation.
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Product Details
| Alternative Name: | Cyclooxygenase, Prostaglandin H synthase |
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| Sensitivity: | 0.147 Units/ml COX-I (range 7.5 - 60 Units/ml) |
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| Applications: | Chemiluminescence
Activity assay
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| Application Notes: | For the measurement of COX-1 and COX-2 activity. |
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| Use/Stability: | Store all components at 4°C, except Inhibitors at -20°C. |
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| Shipping: | Dry Ice and Blue Ice |
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| Contents: | Microtiter plate, Chemiluminescent substrate, Ibuprofen, Meloxicam |
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| Scientific Background: | Cyclooxygenases-1 and 2 (COX-1 and COX-2) also known as Prostaglandin endoperoxide H synthases-1 and 2 are integral membrane proteins which catalyze the first step of prostaglandin, thromboxane, and prostacyclin production from arachidonic acid. The COX-1 and COX-2 enzymes are important pharmacologically as targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, ibuprofen and the COX-2 inhibitors. Inhibition of cyclooxygenases with NSAIDs acutely reduces inflammation, pain, and fever. |
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| UniProt ID: | P23219 (COX-1), P35354 (COX-2) |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Insight into the molecular mechanism of an herbal injection by integrating network pharmacology and in vitro: Y.M. Ma, et al.; J. Ethnopharmacol.
173, 91 (2015),
Application(s): Chemiluminescence,
Abstract;
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