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COX activity kit

 
ADI-907-003 96 wells 465.00 USD
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  • Fast - results in less than 2 hours from up to 40 samples in duplicate
  • Flexible - evaluate COX-1 and/or COX-2 inhibitors
  • Precise - intra-assay variation < 7%
The COX activity kit is the first commercially available non-radioactive COX activity assay. This kit lets you easily evaluate COX I and COX II inhibitors in a convenient 96-well plate based assay with < 7% intra-assay variation.
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Product Details

Alternative Name:Cyclooxygenase, Prostaglandin H synthase
 
Sensitivity:0.147 Units/ml COX-I (range 7.5 - 60 Units/ml)
 
Applications:Chemiluminescence
Activity assay
 
Application Notes:For the measurement of COX-1 and COX-2 activity.
 
Use/Stability:Store all components at 4°C, except Inhibitors at -20°C.
 
Shipping:Shipped on Blue Ice
 
Contents:Microtiter plate, Chemiluminescent substrate, Ibuprofen, Meloxicam
 
Scientific Background:Cyclooxygenases-1 and 2 (COX-1 and COX-2) also known as Prostaglandin endoperoxide H synthases-1 and 2 are integral membrane proteins which catalyze the first step of prostaglandin, thromboxane, and prostacyclin production from arachidonic acid. The COX-1 and COX-2 enzymes are important pharmacologically as targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, ibuprofen and the COX-2 inhibitors. Inhibition of cyclooxygenases with NSAIDs acutely reduces inflammation, pain, and fever.
 
UniProt ID:P23219 (COX-1), P35354 (COX-2)
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Insight into the molecular mechanism of an herbal injection by integrating network pharmacology and in vitro: Y.M. Ma, et al.; J. Ethnopharmacol. 173, 91 (2015), Application(s): Chemiluminescence, Abstract;

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