Product Details
| Alternative Name: | Kidney Injury Molecule-1, HAVcr-1, TIMD-1, TIM-1, Hepatitis A virus cellular receptor 1 homolog, T cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin mucin receptor, CD365 |
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| Clone: | 3F4 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant human KIM-1. |
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| UniProt ID: | Q96D42.2 |
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| Source: | Purified from mouse ascites. |
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| Species reactivity: | Human
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| Applications: | ELISA, Flow Cytometry, WB
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Kidney Injury Molecule-1 (KIM-1) is a type 1 transmembrane protein, with an immunoglobulin and mucin domain, whose expression is markedly up-regulated in the proximal tubule in the post-ischemic rat kidney. KIM-1 is a potential biomarker for renal injury or renal inflammation. It is a traditional blood and urine marker for the diagnosis of various renal diseases. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of KIM-1 (human), mAb (3F4) (Prod. No. ADI-905-906): Lane 1: MW marker, Lane 2: HeLa, (cell lysate) (Prod. No. ADI-LYC-HL100), Lane 3: CaKi-2 (cell lysate).
Flow cytometry analysis of 106 CaKi-2 cells stained using KIM-1 (human), mAb (3F4), FITC Conjugate at concentrations of 25µg/ml and 5µg/ml.
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General Literature References
Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics: D. Burt, et al.; Drug Chem. Toxicol.
37, 204 (2014),
Abstract;
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