| Alternative Name: | CB2, CNR2 |
| |
| Host: | Rabbit |
| |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of rat cannabinoid receptor CB2. |
| |
| UniProt ID: | Q9QZN9 |
| |
| Species reactivity: | Rat
|
| |
| Crossreactivity: | Predicted species reactivity based on epitope sequence homology: human, mouse, bovine, horse, rhesus macaque, dog, chimpanzee. |
| |
| Applications: | WB
|
| |
| Application Notes: | Predicted MW of ~35kDa. Higher MW species (~50kDa) and intermediates also observed by Western blot which reflect post-translational modification of the receptor. |
| |
| Purity Detail: | Peptide affinity purified. |
| |
| Formulation: | Liquid. In PBS containing 50% glycerol and 0.01% sodium azide. |
| |
| Handling: | Keep on ice at all times. |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Scientific Background: | The cannabinoid receptors CB1 and CB2 are members of the seven-transmembrane family of G-protein coupled receptors (GPCRs), and are named for their signaling function in response to cannabinoid drugs such as delta 9- tetrahydrocannabinol (delta 9-THC). CB1 and CB2 differ significantly in the length of their extracellular amino terminal domain, which is longer in CB1 (116 residues) than in CB2 (33 residues). The CB1 receptor is expressed primarily in the brain and neuronal tissue, and is highly conserved, exhibiting 97-98% amino acid sequence identity across human, mouse, and rat species. In contrast, expression of the CB2 receptor is absent in normal nervous tissue, with expression most prominent in immune tissue such as the spleen. In addition to delta 9-THC and its synthetic analogs, CB1 and CB2 receptors are bound by endogenous eicosanoid ligands, and signal via Gi/o proteins to regulate adenylyl cyclase activity (generally inhibitory), ion channel activation, intracellular Ca2+ levels, nitric oxide synthase activation, and immediate early gene expression. CB1 and CB2 signals in turn regulate neurological and immunological functions such as inhibition of neurotransmitter release and immune cell migration, antigen processing, and cytokine production. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
| Manufacturer: | Manufactured by Proteimax. |
| |
