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Substance P receptor NK1 polyclonal antibody

ADI-905-801-100 100 µg 362.00 USD
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Product Details

Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of rat substance P receptor NK1.
UniProt ID:P14600
Species reactivity:Rat
Crossreactivity:Predicted species reactivity based on epitope sequence homology: mouse, human, gerbil, opossum, chimpanzee, guinea pig, bovine, rhesus macaque, dog, guinea pig, Gallus.
Applications:ELISA, WB
Application Notes:Suitable for membrane-based ELISA.
Predicted MW of ~46kDa. Higher MW species (~50kDa) and intermediates also observed by Western blot which reflect post-translational modification of the receptor.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
Handling:Keep on ice at all times.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Substance P (SP) is an 11 amino acid member of the tachykinin family of neuropeptides which includes SP, neurokinin-A (NK-A) and neurokinin-B (NK-B), all of which exhibit a common COOH-terminal pentapeptide sequence Phe-X-Gly-Leu-Met-NH2. SP functions as a neurotransmitter and its effects are associated with physiological processes such as vomiting, pain, and vasodilation. Three tachykinin receptors have been identified to date, NK1, NK2, and NK3, with SP showing preferential affinity for the NK1 receptor. SP signaling occurs primarily via coupling of Gq/11 alpha subunits to NK1, leading to phospholipase C activation. High SP concentrations may also stimulate adenylyl cyclase activity, resulting in elevated cAMP.
Regulatory Status:RUO - Research Use Only
Manufacturer:Manufactured by Proteimax.
Substance P receptor NK1 polyclonal antibody Western blot
Western blot analysis: MW marker (1) and 25µg rat brain extract (2) probed with Substance P Receptor (NK1) pAb at 3.7µg/ml
Substance P receptor NK1 polyclonal antibody Membrane ELISA
Membrane ELISA: Lewis rat striatum membranes (5µg/well) were treated with 1 μM concentrations of agonist (Substance P) and probed with Substance P Receptor (NK1) pAb (1:250 to 1:2000 of a 1µg/μl stock solution) by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=4).
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Substance P receptor NK1 polyclonal antibody Western blot Substance P receptor NK1 polyclonal antibody Membrane ELISA

Product Literature References

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states: A.S. Heimann, et al.; PloS One 12, e0187306 (2017), Abstract; Full Text

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