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Opioid receptor κ polyclonal antibody

ADI-905-799-100 100 µg 397.00 USD
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Product Details

Alternative Name:OPRK1, KOR-1
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of mouse opioid receptor κ.
UniProt ID:P33534
Species reactivity:Human, Mouse, Rat
Crossreactivity:Predicted species reactivity based on epitope sequence homology: dog, bovine, horse.
Applications:ELISA, IHC, WB
Application Notes:Suitable for cell-based and membrane-based ELISA.
Predicted MW of ~43kDa. Higher MW species (~50kDa) and intermediates also observed by Western blot which reflect post-translational modification of the receptor.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
Handling:Keep on ice at all times.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:The opioid receptors delta (DOP, OP1), kappa (KOP, OP2), and mu (MOP, OP3) are members of the seven-transmembrane domain-containing receptor family of G-protein coupled receptors, sharing nearly 60% identity, but varying greatly in the extracellular N-terminus region of the receptors. The delta, kappa and mu-receptors serve as functional receptors for endogenous enkephalin, dynorphin, and beta-endorphin peptide ligands, respectively, mediating their signal via coupling to Gi/o alpha subunits to inhibit adenylyl cyclases and calcium conductance (N- and L-type channels), and to stimulate MAPK activation and potassium conductance. Delta-opioid receptors are highly expressed in the olfactory bulb, neocortex, caudate putamen and nucleus accumbens, with peripheral expression in the gastro-intestinal tract and vas deferens. Delta-opioid receptors function to inhibit neurotransmitter release resulting in a variety of biological effects including analgesia, motor integration, gastro-intestinal motility, olfaction,
Regulatory Status:RUO - Research Use Only
Manufacturer:Manufactured by Proteimax.
Opioid receptor κ polyclonal antibody Western blot
Western blot analysis: MW marker (1) and 50µg rat brain extract (1) probed with Opioid Receptor kappa pAb at 1µg/ml
Opioid receptor κ polyclonal antibody Membrane ELISA
Membrane ELISA: Lewis rat striatum membranes (5µg/well) were treated with 1 μM concentrations of agonist (Endorphin B) and probed with Opioid Receptor kappa pAb (1:250 to 1:2000 of a 1µg/μl stock solution) by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=4).
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Opioid receptor κ polyclonal antibody Western blot Opioid receptor κ polyclonal antibody Membrane ELISA

Product Literature References

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states: A.S. Heimann, et al.; PloS One 12, e0187306 (2017), Abstract; Full Text

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