Product Details
| Alternative Name: | Acetylcholine muscarinic receptor 1, Cholinergic muscarinic receptor 1 |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of rat muscarine receptor M1. |
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| UniProt ID: | P04761 |
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| Species reactivity: | Rat
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| Crossreactivity: | Predicted species reactivity based on epitope sequence homology: human, mouse, horse, bovine, guinea pig, dog, orangutan, chimpanzee, wild boar, rhesus macaque, opossum. |
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| Applications: | WB
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| Application Notes: | Predicted MW of ~51kDa. |
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| Purity Detail: | Peptide affinity purified. |
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| Formulation: | Liquid. In PBS containing 50% glycerol and 0.01% sodium azide. |
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| Handling: | Keep on ice at all times. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | The pharmacologic activity of acetylcholine (ACTH) is mediated by the ionotropic nicotinic receptor or via metabotropic muscarinic receptors. Five known acetylcholine (muscarinic) receptors (M1-M5) are variably expressed in the central nervous system and periphery, mediating motor control, thermoregulation, memory, smooth muscle contraction, glandular secretion, and cardiac function. Although the physiology of the five mammalian muscarinic receptor homologs does not differ significantly in their affinities to a variety of agonists (ACTH, muscarine) and antagonists (e.g., atropine), they can be divided into two sub-groups (M1/M3/M5 and M2/M4) based on G alpha subunit coupling preferences. M1/M3/M5 receptors signal primarily via Gq/11 alpha subunits to stimulate phospholipase C, whereas M2/M4 receptors couple to Gi/o alpha subunits to inhibit adenylyl cyclases and cAMP production. Modulation of muscarinic receptor activity holds promise for the treatment of psychiatric and neurological disorders including schizophrenia and Alzheimer's disease. |
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| Regulatory Status: | RUO - Research Use Only |
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| Manufacturer: | Manufactured by Proteimax. |
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Western blot analysis: MW marker (1) and 10µg of rat brain extract (2) probed with Muscarine Receptor (M1) pAb at 3µg/ml.
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Product Literature References
Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states: A.S. Heimann, et al.; PloS One
12, e0187306 (2017),
Abstract;
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