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LTB4 receptor (BLT2) polyclonal antibody

 
ADI-905-794-100 100 µg 304.00 USD
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Product Specification

Alternative Name:Leukotriene B4 Receptor 2, LTB4-R2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of rat LTB4 Receptor (BLT2).
 
UniProt ID:Q924U0
 
Species reactivity:Rat
 
Crossreactivity:Predicted species reactivity based on epitope sequence homology: human, mouse, horse, chimpanzee, rhesus macaque, wild boar, dog, platypus.
 
Applications:WB
 
Application Notes:Predicted MW of ~38kDa. Higher MW species (~50kDa) and intermediates also observed by Western blot which reflect post-translational modification of the receptor.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
 
Handling:Keep on ice at all times.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Leukotrienes are metabolic products of arachidonic acid formed by the action of 5-lipoxygenase (5-LO), with the principal products being leukotrienes C4 (LTC4) and B4 (LTB4). LTB4 is a dihydroxy-leukotriene produced in a variety of cells including eosinophils, neutrophils, platelets, and vascular cells, and is a potent leukocyte chemoattractant known to regulate leukocyte activation, cytokine secretion, inflammatory gene transcription, and IgE synthesis. As such, LTB4 has been implicated in a number of disease pathologies including atherosclerosis, asthma, psoriasis, and inflammatory bowel disease. The many actions of LTB4 are associated with two identified mammalian receptors, BLT1 and BLT2. BLT1 is a high-affinity LTB4 receptor expressed on peripheral leukocytes, while BLT2 is a more ubiquitously expressed low affinity LTB4 receptor whose function is not well understood. The BLT1 receptor is transiently expressed by antigen-primed T-cells in humans, and its expression is known to play a critical role in collagen-induced arthritis in mice.
 
Regulatory Status:RUO - Research Use Only
 
Manufacturer:Manufactured by Proteimax.
 
LTB4 receptor (BLT2) polyclonal antibody Western blot
Western blot analysis: MW marker (1) and 50µg rat heart membrane extract (2) probed with LTB4 Receptor (BLT2) pAb at 2.5µg/ml.
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LTB4 receptor (BLT2) polyclonal antibody Western blot

Product Literature References

Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells: J. Park, et al.; Biochim. Biophys. Acta Mol. Cell. Res. 1866, 329 (2019), Application(s): Western Blot, Abstract;
Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states: A.S. Heimann, et al.; PloS One 12, e0187306 (2017), Abstract; Full Text
Leukotriene B4 receptor-2 contributes to chemoresistance of SK-OV-3 ovarian cancer cells through activation of signal transducer and activator of transcription-3-linked cascade: J. Park, et al. ; Biochim. Biophys. Acta 1863, 236 (2015), Application(s): Flow cytometric analysis for BLT2 expression, Abstract;

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