| Alternative Name: | Glycogen synthate kinase-3α |
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| Clone: | 9B8 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Phosphopeptide conjugated to KLH. |
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| UniProt ID: | P49840 |
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| Species reactivity: | Human, Mouse, Rat
Dog
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| Specificity: | Recognizes GSK-3α phosphorylated at Ser21. |
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| Crossreactivity: | Does not cross-react with the homologous phosphorylation site in GSK-3β (pSer9). |
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| Applications: | ELISA, WB
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| Purity Detail: | Thiophilic adsorption and size exclusion chromatography purified. |
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| Formulation: | Lyophilized from 1ml of 2x PBS containing 0.09% sodium azide, PEG, and sucrose. |
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| Reconstitution: | Reconstitute with 1ml water (15 minutes at room temperature). |
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| Use/Stability: | Reconstituted antibody is stable at -80°C up to 1 year, at 4°C up to 3 months. |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: |
Glycogen Synthase Kinase 3 (GSK3) exists in two isoforms, alpha and beta (GSK3α, and GSK3β). GSK3 is an active kinase that becomes phosphorylated by PKB/akt upon growth factor stimulation. Phosphorylation of GSK3α at serine 21 or GSK3β at serine 9, respectively, leads to inhibition of kinase activity of the GSK3. |
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| Regulatory Status: | RUO - Research Use Only |
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![[pSer21]GSK-3α monoclonal antibody (9B8) Western blot](https://www.enzolifesciences.com/fileadmin/files/image/905-759_WB.jpg "[pSer21]GSK-3α monoclonal antibody (9B8) Western blot")
![[pSer21]GSK-3α monoclonal antibody (9B8) Western blot](https://www.enzolifesciences.com/fileadmin/thumbs/074dae3d03c19b5f38b6c7d05c9a5b360d11f51b-905-759_WB.jpg.jpg "[pSer21]GSK-3α monoclonal antibody (9B8) Western blot")
