| ADI-905-736-100 | 100 µg | 468.00 USD |  |
||
| Do you need bulk/larger quantities? | |||||
| Alternative Name: | γ-secretase subunit PEN-2, Presenilin enhancer protein 2 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of human PEN2. |
| UniProt ID: | Q9NZ42 |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | IHC, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (10µg/ml) Western Blot (0.5-1.0µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | PEN2, in addition to nicastrin, presenilin, and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is thought to be required for the generation of neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimers disease. Gamma- secretase will cleave the amyloid precursor protein (APP) within the intramembrane region, resulting in either the nontoxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). |
| Regulatory Status: | RUO - Research Use Only |
