| ADI-905-731-100 | 100 µg | 433.00 USD |  |
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| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the middle of human BMI-1. |
| UniProt ID: | P35226 |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | ICC, WB |
| Recommended Dilutions/Conditions: | Immunocytochemistry (10µg/ml) Western Blot (0.5-1.0µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~33kDa by Western blot. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | +4°C |
| Scientific Background: | The transcriptional repressor BMI-1 was first identified as a proto-oncogene that cooperates with c-myc in the generation of lymphomas in murine models. BMI-1 belongs to the Polycomb-group (PcG) family of proteins involved in axial patterning, hematopoeisis, cell growth, and senescence. A major target of BMI-1 is the INK4A/ARF locus which encodes tumor suppressor proteins p16 and p19ARF. Studies have also shown that BMI-1 is overexpressed in numerous human cancers, including lymphomas, breast, colorectal, and prostate cancers. |
| Regulatory Status: | RUO - Research Use Only |
