| ADI-905-729-100 | 100 µg | 478.00 USD |  |
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| Alternative Name: | Activating transcription factor 6 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of human ATF6. |
| UniProt ID: | P18850 |
| Species reactivity: | Human, Mouse |
| Applications: | ICC, WB |
| Recommended Dilutions/Conditions: | Immunocytochemistry (10µg/ml) Western Blot (0.5-1.0µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~88kDa by Western blot. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | -20°C |
| Scientific Background: | Disruptions of protein folding and maturation in the endoplasmic reticulum (ER) result in the activation of the unfolded protein response (UPR), an integrated cellular signaling pathway that transmits information from the ER lumen to the cytoplasm and nucleus. Activating transcription factor 6 (ATF6) as well as the ER-transmembrane protein kinases IRE1p and PERK are the major transducers of the UPR. ATF6 is an ER transmembrane protein that is normally bound to the ER chaperone Grp78, but upon ER stress is released from Grp78 and proteolytically cleaved to yield a cytosolic fragment which then migrates to the nucleus. Nuclear ATF6, together with the transcription factor XBP-1, activates transcription of UPR-responsive genes. |
| Regulatory Status: | RUO - Research Use Only |
