| ADI-905-727-100 | 100 µg | 467.00 USD |  |
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| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human IRE1p. |
| UniProt ID: | O75460 |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | ICC, WB |
| Recommended Dilutions/Conditions: | Immunocytochemistry (1µg/ml) Western Blot (1-2µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~110kDa by Western blot. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and upregulation of the ER molecular chaperones GRP78 and GRP94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress induces their dissociation. This allows IRE1p, a serine-threonine protein kinase, to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also functions as an endoribonuclease to splice X-box binding protein (XBP1) mRNA, converting it to a potent UPR transcriptional activator. |
| Regulatory Status: | RUO - Research Use Only |
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