Product Details
Alternative Name: | Toll-like receptor 3 |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human TLR3. |
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UniProt ID: | O15455 |
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Species reactivity: | Human, Mouse
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Applications: | ICC, WB
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Recommended Dilutions/Conditions: | Immunocytochemistry (1µg/ml) Western Blot (1-2µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~106kDa by Western blot. |
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Purity Detail: | Affinity chromatography purified via peptide column. |
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Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | The TLRs (Toll-like receptors) are a group of evolutionarily conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine-rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands. |
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Regulatory Status: | RUO - Research Use Only |
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Immunocytochemistry analysis of TLR3 in EL4 cells with TLR3 antibody at 1µg/ml.
Western blot analysis of TLR3 in Daudi cell lysate with TLR3 antibody at (A) 1 and (B) 2µg/ml.
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Product Literature References
Toll-like receptor 3 signaling contributes to the expression of a neutrophil chemoattractant, CXCL1 in human mesangial cells: T. Imaizumi, et al.; Clin. Exp. Nephrol.
19, 761 (2015),
Abstract;
Interaction between interferon-stimulated gene 56 and melanoma differentiation-associated gene 5 in Toll-like receptor 3 signaling in normal human mesangial cells: T. Imaizumi, et al.; Am. J. Nephrol.
37, 118 (2013),
Abstract;
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