| ADI-905-724-100 | 100 µg | 455.00 USD |  |
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| Alternative Name: | PDZ protein interacting specifically with TC10 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human PIST. |
| UniProt ID: | Q9HD26 |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | IHC, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (1µg/ml) Western Blot (1-2µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | +4°C |
| Scientific Background: | Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells. Golgi-associated PIST (PDZ domain protein interacting specifically with TC10) has been characterized by its ability to bind and regulate the expression of membrane associated proteins. A neural isoform of PIST (nPIST) has been linked to autophagy and neurodegenerative disease by mediating the interaction between the delta2-glutamate receptor and Beclin-1, a Bcl-2-interacting protein homolog of the yeast autophagy gene apg6. |
| Regulatory Status: | RUO - Research Use Only |
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