Product Details
| Alternative Name: | Interleukin-1 receptor-associated kinase 1 |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human IRAK-1. |
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| UniProt ID: | P51617 |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | ICC, IP, WB
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| Purity Detail: | DEAE purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | IRAK (IL-1 associated serine/threonine kinase) is a critical regulator of IL-1 induced activation of the NF-κB pathway. IL-1 stimulates the association of IRAK with the heterodimer of IL-IRI and IL-IRAcP via the adapter protein MyD88. In addition to its role in IL-1 signaling, IRAK is a component of the signal transduction pathway through which TNF-R1 activates NF-κB dependent gene expression. |
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| Regulatory Status: | RUO - Research Use Only |
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Immunocytochemistry analysis of IRAK in HeLa cells with IRAK antibody at 10µg/ml.
Western blot analysis of IRAK in THP-1 (THP) and HeLa (HL) whole cell lysates with IRAK antibody at 1:2000 dilution.
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Product Literature References
Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways: H.F. Huang, et al.; World J. Gastroenterol.
21, 2937 (2015),
Application(s): Western Blotting,
Abstract;
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