| ADI-905-684-100 | 100 µg | 310.00 USD |  |
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| Alternative Name: | Second mitochondria-derived activator of caspase |
| Clone: | 79-1-83 |
| Host: | Mouse |
| Isotype: | IgG2b |
| Immunogen: | Recombinant full length human Smac/DIABLO. |
| UniProt ID: | Q9NR28 |
| Source: | Purified from mouse ascites. |
| Species reactivity: | Human Monkey |
| Applications: | IHC (PS), WB |
| Recommended Dilutions/Conditions: | Western Blot (1µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate. |
| Regulatory Status: | RUO - Research Use Only |
HeLa, (cell lysate) |
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| Human, WB | Print as PDF | ||||||
| ADI-LYC-HL100-F | 200 µg | 141.00 USD | |
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