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Insulin receptor β monoclonal antibody (C18C4)

ADI-905-683-100 100 µg 373.00 USD
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Product Details

Alternative Name:INSR
Immunogen:Recombinant cytoplasmic domain of human Insulin Receptor β.
UniProt ID:P06213
Source:Purified from ascites.
Species reactivity:Human, Mouse, Rat
Bovine, Hamster, Porcine, Rabbit, Sheep
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~98kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.
Regulatory Status:RUO - Research Use Only
Insulin receptor β monoclonal antibody (C18C4) Western blot
Western blot analysis of ADI-905-683: Lane 1: MW Marker, Lane 2: HeLa lysate, Lane 3: MCF-7 lysate, Lane 4: PC-12 lysate, Lane 5: 3T3 lysate.
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Insulin receptor β monoclonal antibody (C18C4) Western blot

Product Literature References

Liver glucose-6-phosphatase proteins in suckling and weaned grey seal pups: structural similarities to other mammals and relationship to nutrition, insulin signalling and metabolite levels: K.A. Bennett, et al.; J. Comp. Physiol. B 183, 1075 (2013), Abstract;

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Insulin receptor Monoclonal antibody
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