| ADI-905-652-100 | 100 µg | 551.00 USD |  |
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| Alternative Name: | MKK1/MKK2, MAP kinase kinase 1/2 |
| Clone: | 7E10 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide corresponding to a portion of MEK1 phosphorylated at Ser218/222and MEK2 phosphorylated at Ser222/226 , conjugated to KLH. |
| UniProt ID: | Q02750 (MEK1), P36507 (MEK2) |
| Species reactivity: | Human, Mouse Dog |
| Applications: | ELISA, WB |
| Recommended Dilutions/Conditions: | ELISA (0.1µg/ml) Western Blot (0.5µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~45kDa by Western blot. |
| Purity Detail: | Thiophilic adsorption and size exclusion chromatography purified. |
| Formulation: | Lyophilized from 1ml of 2x PBS containing 0.09% sodium azide, PEG, and sucrose. |
| Reconstitution: | Reconstitute with 1ml water (15 minutes at room temperature). |
| Use/Stability: | Stable at -80°C up to 1 year, at 4°C up to 3 months. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | MEK is a dual specificity kinase capable of phosphorylating both tyrosine and threonine residues. The MEK family, which is also known as MAP kinase kinase, phosphorylates MAP kinases on the conserved T-X-Y motif; phosphorylation of MAPK by MEK results in an increase in MAPK activity. MEK is involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis. |
| Regulatory Status: | RUO - Research Use Only |
![[pSer218/222]MEK1 and [pSer222/226]MEK2 monoclonal antibody (7E10) Western blot](https://www.enzolifesciences.com/fileadmin/files/image/905-652_WB.jpg "[pSer218/222]MEK1 and [pSer222/226]MEK2 monoclonal antibody (7E10) Western blot")
![[pSer218/222]MEK1 and [pSer222/226]MEK2 monoclonal antibody (7E10) Western blot](https://www.enzolifesciences.com/fileadmin/thumbs/af7a752810914d195559c4eb324bae127cb4c220-905-652_WB.jpg.jpg "[pSer218/222]MEK1 and [pSer222/226]MEK2 monoclonal antibody (7E10) Western blot")
